Scripted interactions are story sequences told through the use of on-screen text descriptions, illustrations, and sounds. They are used to emphasize events, and offer different choices to solve an event outside the typical realms of combat and person-to-person dialogue. The options often require character attribute and skill checks e.g. Physical options like lifting something with a strength stat or stealing with dexterity.  These checks are sometimes for the character interacting with the scene, and other times for the whole party. Characters can become injured, or in some cases killed by being below the threshold of an attribute or skill check in a scripted interaction. 
|“||Josh Sawyer: Because this is all taking place in imagination land, it can be whatever we feel fits with that. The player could use their strength to push over a statue. Or there’s a lock. The lock is to move the statue out of the way. If you have a high mechanic skill, you can pick that lock. If you don’t, a guy with high strength can just take the statue and be like, ‘EAAARRRGH!’ and just shove it. We want to make it feel like, if you were sitting at a table with a DM, you’d say, ‘Hey, my dude has 20 strength. I want to fuckin’ push that thing over.’ That’s the great thing about scripted interactions or dialogues that allow you to do that. You can just say, ‘Sure, yep, okay!’ Because it’s more about the description and your imagination, not about, ‘Oh, we have to animate this.’||”|
In some interactions you can use an item to get what you want. Those items are consumed if they are used and can either make a skill check easier or are needed to get the best result. You can either find them in the world or buy them. Other times you can use quest items like keys in scripted interactions. Known items:
In Pillars of Eternity
In Pillars of Eternity II: Deadfire
Scripted interactions are a staple of Pillars of Eternity II: Deadfire, and are much more prevalent than they were in Pillars of Eternity. In addition to the dozens of interactions during quests and while navigating areas in general, many points on the world map that don't open into a player-navigable area are dedicated scripted interactions, and will disappear once the interaction has been completed.